Competing/conflicts of interest: No stated conflict of interest.
Proteomic analysis of ophthalmic disease
Article first published online: 9 OCT 2012
© 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists
Clinical & Experimental Ophthalmology
Volume 40, Issue 7, pages 755–763, September/October 2012
How to Cite
Jay, N. L. and Gillies, M. (2012), Proteomic analysis of ophthalmic disease. Clinical & Experimental Ophthalmology, 40: 755–763. doi: 10.1111/j.1442-9071.2012.02788.x
Funding sources: No stated funding sources.
- Issue published online: 9 OCT 2012
- Article first published online: 9 OCT 2012
- Accepted manuscript online: 7 MAR 2012 07:28AM EST
- Received 1 February 2012; accepted 13 February 2012.
Proteomics, a highly sophisticated way to study the protein profile of various biological tissues or fluids, has hitherto had a relatively limited role ophthalmic science. Of the few proteomic studies that have been performed, liquid chromatography, electrophoresis gel separation and mass spectrometry have been utilized to investigate the proteome of several different eye structures and fluids from both humans and animal models. Ophthalmic proteomic studies have so far attempted to identify proteins unique to the eye, to investigate protein changes due to the onset of various diseases and to identify proteins that could act as markers of disease. Proteomics has the potential to improve the way in which eye disease is diagnosed and potentially even treated by identifying novel pathogenic pathways that may be susceptible to therapeutic manipulation. The aim of this review is to give an overview the current and potential application of proteomic science to ophthalmic research.