Competing/conflicts of interest: No stated conflict of interest.
Correlation between optic nerve head parameters and retinal nerve fibre layer thickness measured by spectral-domain optical coherence tomography in myopic eyes
Version of Record online: 4 JUN 2012
© 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists
Clinical & Experimental Ophthalmology
Volume 40, Issue 7, pages 713–720, September/October 2012
How to Cite
Hwang, Y. H. and Kim, Y. Y. (2012), Correlation between optic nerve head parameters and retinal nerve fibre layer thickness measured by spectral-domain optical coherence tomography in myopic eyes. Clinical & Experimental Ophthalmology, 40: 713–720. doi: 10.1111/j.1442-9071.2012.02793.x
Funding sources: No stated funding sources.
- Issue online: 9 OCT 2012
- Version of Record online: 4 JUN 2012
- Accepted manuscript online: 19 MAR 2012 09:42AM EST
- Received 5 October 2011; accepted 19 February 2012.
- optic nerve head;
- optical coherence tomography;
- retinal nerve fibre layer
Background: To evaluate the correlation between optic nerve head parameters and retinal nerve fiber layer thickness measured by Cirrus HD spectral-domain optical coherence tomography (Cirrus HD-OCT; Carl Zeiss Meditec) in healthy myopic eyes.
Design: Cross-sectional study.
Participants: One hundred and sixty-one right eyes from 161 healthy young myopic subjects.
Methods: Optic nerve head parameters and retinal nerve fiber layer thickness were measured with the Cirrus HD-OCT. The distance between optic disc margin and scan circle (disc margin-to-scan distance) was measured on the Cirrus HD-OCT en-face optic nerve head image with aid of National Institutes of Health ImageJ image-analysis software (developed by Wayne Rasbands, National Institutes of Health, Bethesda, MD).
Main Outcome Measures: The correlations among optic nerve head parameters, retinal nerve fibre layer thickness and the disc margin-to-scan distance were evaluated with and without adjustment of the magnification effect.
Results: Without correction of the magnification effect, the thicker average retinal nerve fiber layer was correlated with greater rim area and lower degree of myopia (P < 0.001). When the magnification effect was corrected, thicker average retinal nerve fibre layer was associated with greater disc area and greater rim area in univariate and multivariate analyses (P ≤ 0.028); however, degrees of myopia and the disc margin-to-scan distance were not significantly associated with average RNFL thickness (P ≥ 0.104).
Conclusions: Thicker average retinal nerve fibre layer thickness was associated with greater rim and disc areas. Disc margin-to-scan distance was not significantly correlated with average retinal nerve fibre layer thickness in healthy myopic eyes.