Competing/conflicts of interest: No stated conflict of interest.
Long-term risk of intraocular pressure elevation and glaucoma escalation after deep anterior lamellar keratoplasty
Article first published online: 25 MAY 2012
© 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists
Clinical & Experimental Ophthalmology
Volume 40, Issue 8, pages 780–785, November 2012
How to Cite
Musa, F. U., Patil, S., Rafiq, O., Galloway, P., Ball, J. and Morrell, A. (2012), Long-term risk of intraocular pressure elevation and glaucoma escalation after deep anterior lamellar keratoplasty. Clinical & Experimental Ophthalmology, 40: 780–785. doi: 10.1111/j.1442-9071.2012.02796.x
Funding sources: No stated funding sources.
- Issue published online: 7 NOV 2012
- Article first published online: 25 MAY 2012
- Accepted manuscript online: 19 MAR 2012 09:46AM EST
- Received 20 November 2011; accepted 25 February 2012.
- lamellar keratoplasty;
- ocular hypertension
Background: To determine the prevalence and severity of intraocular pressure changes after deep anterior lamellar keratoplasty and its effect on visual function.
Design: Retrospective cohort study.
Participants: All patients undergoing deep anterior lamellar keratoplasty procedures at a tertiary referral centre (Leeds University Hospitals, UK) using a manual dissection technique.
Methods: Case note review of all cases between the 1st of January 2000 and the 31st of December 2005.
Main Outcome Measures: Raised intraocular pressure, glaucoma incidence or escalation.
Results: Data were collected for 69 of eyes of 58 patients. The mean period of follow-up was 54.9 months (median 60, range 6–95 months). The initial diagnosis was keratoconus in 56 cases (81%), corneal scarring in four cases (5.8%), herpes simplex keratitis in four cases (5.8%), lattice dystrophy in four cases (5.8%) and one case of corneal dermoid. Temporarily intraocular pressure was thought to be related to topical steroid use occurred in 12 (17%) cases. Ocular hypertension requiring treatment occurred in three eyes. None of these eyes had progressive disc changes or visual field defects suggestive of glaucoma, and all had well-controlled intraocular pressure on topical, single-drug therapy. Overall, there was a small insignificant rise in intraocular pressure after deep anterior lamellar keratoplasty (P = 0.11).
Conclusions: The long-term risk of glaucoma following deep anterior lamellar keratoplasty using the manual dissection technique appears to be low. Ocular hypertension after deep anterior lamellar keratoplasty is infrequent and can be controlled on topical medication alone.