Competing/conflicts of interest: No stated conflict of interest.
Association between myopia and diabetic retinopathy: a review of observational findings and potential mechanisms
Version of Record online: 29 OCT 2012
© 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists
Clinical & Experimental Ophthalmology
Volume 41, Issue 3, pages 293–301, April 2013
How to Cite
Man, R. E., Sasongko, M. B., Wang, J. J. and Lamoureux, E. L. (2013), Association between myopia and diabetic retinopathy: a review of observational findings and potential mechanisms. Clinical & Experimental Ophthalmology, 41: 293–301. doi: 10.1111/j.1442-9071.2012.02872.x
Funding sources: The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government.
- Issue online: 9 APR 2013
- Version of Record online: 29 OCT 2012
- Accepted manuscript online: 7 SEP 2012 06:48AM EST
- Manuscript Accepted: 10 AUG 2012
- Manuscript Received: 7 JUN 2012
- Victorian Government
- anterior chamber depth;
- axial length;
- ocular biometric parameter;
- refractive error
A protective, but inconsistent association between myopia and a decreased risk of diabetic retinopathy (DR) has been suggested in several studies. However, it is unclear whether the structural, or the refractive components of myopia; or both, is the main contributor to this protective relationship. This paper provides a comprehensive review of existing evidence on the association between myopia, and its structural (axial length [AL], anterior chamber depth [ACD]) and refractive (lens biometry and corneal curvature [CC]) components, with DR. 11 studies consisting of 7230 subjects from 1960 to April 2012, were reviewed. A longer AL was the only variable associated with a lower risk and severity of DR. Therefore, the available evidence suggests that AL is the main contributor to the protective influence of myopia on DR observed in earlier studies. Further investigations are now needed to determine the mechanisms by which AL protects against DR.