This paper was the basis of a presentation at the Australian Vision Convention annual meeting on 13 April 2012, Queensland, Australia, on the occasion of the presentation of the H Barry Collin Research Medal to Anthony J Adams.
Retinal neuropathy precedes vasculopathy in diabetes: a function-based opportunity for early treatment intervention?
Version of Record online: 13 APR 2012
© 2012 The Authors. Clinical and Experimental Optometry © 2012 Optometrists Association Australia
Clinical and Experimental Optometry
This special issue on Diabetes and the Eye has been co-ordinated by Professor Nathan Efron and Associate Professor Erica Fletcher
Volume 95, Issue 3, pages 256–265, May 2012
How to Cite
Adams, A. J. and Bearse Jr, M. A. (2012), Retinal neuropathy precedes vasculopathy in diabetes: a function-based opportunity for early treatment intervention?. Clinical and Experimental Optometry, 95: 256–265. doi: 10.1111/j.1444-0938.2012.00733.x
- Issue online: 17 MAY 2012
- Version of Record online: 13 APR 2012
- Submitted: 5 December 2011; Revised: 12 January 2012; Accepted for publication: 17 January 2012
Diabetes, now at epidemic levels, can have devastating effects on the eye and vision. Treatments of the ocular complications are currently focused on relatively advanced stages and are limited to the slowing down of the progressive sight-threatening retinal vasculopathy (diabetic retinopathy). Tiny signals from the neural retina have been shown to reveal early diabetic neuropathy prior to vascular retinopathy. These signals, in a clinical test format, are predictive, by precise retinal location, of impending vasculopathy in the retina within a year, including sight-threatening oedema. The discovery opens possibilities for the future development of treatments to prevent the onset of retinopathy and the more sight-threatening retinal oedema and changes patient management strategies.