• Eleutherococcus senticosus;
  • non-specific immunity;
  • olive flounder;
  • Paralichthys olivaceus;
  • Siberian ginseng

ABSTRACT:  To determine the effects of Siberian ginseng residuum extract (SG-RE) Eleutherococcus senticosus on non-specific immunity in olive flounder Paralichthys olivaceus, the fish were provided either a commercial diet or a diet supplemented with Siberian ginseng (3 and 7%) for 8 weeks. The fish that were fed a diet supplemented with 3% SG-RE exhibited improved non-specific immunity, not only cellular responses such as phagocytic activity and nitroblue tetrazolium reduction by anterior-kidney leukocytes, but also humoral response such as lysozyme activity in the serum and skin mucus. Moreover, the fish that were provided SG-RE developed resistance to Edwardsiella tarda and Vibrio anguillarum infection.