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Lymph node metastasis of gastric cancer: comparison of Union International Contra Cancer and Japanese systems


  • M. Ikeguchi MD; D. Murakami MD; S. Kanaji MD; S. Ohro MD; Y. Maeta MD; K. Yamaguchi MD; S. Tatebe MD; A. Kondo MD; S. Tsujitani MD; N. Kaibara MD.

Dr Masahide Ikeguchi, Division of Operating Room, Faculty of Medicine, Tottori University, 36−1 Nishi-cho, Yonago 683−8504, Japan.


Background:  The pN classification of gastric cancer (GC) in the Japanese system (Japanese Gastric Cancer Association; JGCA) is based on the site and distance of metastatic nodes from the primary tumour. Union International Contra Cancer (UICC) has recently proposed a classification system based on the number of nodes involved (TNM-1997). The aim of the present study is to assess which classification system is more suitable for providing a prognosis in advanced GC with lymph node metastasis.

Methods:  A total of 224 patients who underwent curative gastrectomy (R0: UICC−TNM and Resection A and B: JGCA) and D2 lymphadenectomy between 1990 and 1999, and diagnosed as pT2, pT3 and pT4 GC were enrolled. Patients were followed until the end of 2002. The disease-free survival rates of patients were compared between the two-stage systems (UICC−TNM and JGCA).

Results:  Using the JGCA system, there was a significant difference between the two survival curves (pN0 and pN1, P = 0.025; pN1 and pN2, P < 0.001; pN2 and pN3, P = 0.031), but the 5-year survival rate of 27 pN2 patients (32.7%) was not significantly different from that of 14 pN3 patients (34.3%, P = 0.994) using the UICC−TNM. In 47 patients with JGCA pN2, the 5-year survival rate of 18 patients with UICC−TNM pN1 (42.9%) was not significantly different from that of 18 patients with UICC−TNM pN2 (25.2%, P = 0.422) or from that of 11 patients with UICC−TNM pN3 (24.2%; P = 0.383).

Conclusions:  The JGCA system is more suitable for estimating the prognosis of Japanese patients with advanced GC than the UICC−TNM.