STEROID HORMONE AND EPIDERMAL GROWTH FACTOR RECEPTORS IN MENINGIOMAS
Article first published online: 21 JAN 2008
Australian and New Zealand Journal of Surgery
Volume 59, Issue 11, pages 881–888, November 1989
How to Cite
Horsfall, D. J., Goldsmith, K. G., Ricciardelli, C., Skinner, J. M., Tilley, W. D. and Marshall, V. R. (1989), STEROID HORMONE AND EPIDERMAL GROWTH FACTOR RECEPTORS IN MENINGIOMAS. Aust. N.Z. J. Surg., 59: 881–888. doi: 10.1111/j.1445-2197.1989.tb07033.x
- Issue published online: 21 JAN 2008
- Article first published online: 21 JAN 2008
- Accepted for publication 28 June 1989.
- epidermal growth factor receptor;
- oestrogen receptor;
- progesterane receptor;
- scatchard analysis
A prospective study of steroid hormone and epidermal growth factor receptor expression in 57 meningiomas is presented. Scatchard analysis of radioligand binding identified 20% of meningiomas as expressing classical oestrogen receptors (ER) at levels below that normally accepted for positivity, the remainder being negative. ER could not be visualized in any meningioma using immunocytochemistry. Alternatively, 74% of meningiomas demonstrated the presence of progesterone receptors (PR) by Scatchard analysis, the specificity of which could not be attributed to glucocorticoid or androgen receptors. Confirmation of classical PR presence was determined by immunocytochemical staining. The presence of epidermal growth factor receptor (EGFR) was demonstrated in 100% of meningiomas using immunocytochemical staining. These data are reviewed in the context of previously reported results and are discussed in relation to the potential for medical therapy as an adjunct to surgery.