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CANCER STEM CELLS: A REVIEW

  1. John B. Spillane†,*,
  2. Michael A. Henderson‡

Article first published online: 9 MAY 2007

DOI: 10.1111/j.1445-2197.2007.04096.x

Issue

ANZ Journal of Surgery

ANZ Journal of Surgery

Volume 77, Issue 6, pages 464–468, June 2007

Additional Information

How to Cite

Spillane, J. B. and Henderson, M. A. (2007), CANCER STEM CELLS: A REVIEW. ANZ Journal of Surgery, 77: 464–468. doi: 10.1111/j.1445-2197.2007.04096.x

Author Information

  1. Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

    J. B. Spillane MB BS, FRACSM. A. Henderson MB BS, MD, FRACS

*Dr John B. Spillane, Department of Surgical Oncology, Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Vic. 3002, Australia. Email: john.spillane@petermac.org

Publication History

  1. Issue published online: 9 MAY 2007
  2. Article first published online: 9 MAY 2007
  3. Accepted for publication 17 December 2006.

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Keywords:

  • acute myeloid leukaemia;
  • breast cancer;
  • cancer stem cells;
  • central nervous system tumours;
  • stem cells;
  • ER;
  • oestrogen receptor

Research has been increasing in recent years into the application of stem cell biology to clinical medicine, particularly its role in the evolution and metastasis of tumours. Stem cells may be the target cell for malignant transformation, and tumour formation could be considered a disorder of stem cell self-renewal pathways. Cancer stem cells have been identified in acute myeloid leukaemia and in breast and central nervous system tumours. Cancer stem cells may have a specific role in tumour metastasis, and their understanding may provide insights into the development of predictive and prognostic markers and specific therapeutic interventions.

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