R. A. Allardyce PhD; P. F. Bagshaw FRCS, FRACS; C. M. Frampton PhD; F. A. Frizelle MMedSc, FACS, FRACS; P. J. Hewett MB BS, FRACS; N. A. Rieger MB, MS, FRACS; J. S. Smith MA; M. J. Solomon MB BCh, MSc, FRACS; A. R. L. Stevenson MB BS, FRACS.
AUSTRALIAN AND NEW ZEALAND STUDY COMPARING LAPAROSCOPIC AND OPEN SURGERIES FOR COLON CANCER IN ADULTS: ORGANIZATION AND CONDUCT†
Article first published online: 8 OCT 2008
© 2008 The Authors Journal compilation © 2008 Royal Australasian College of Surgeons
ANZ Journal of Surgery
Volume 78, Issue 10, pages 840–847, October 2008
How to Cite
Allardyce, R. A., Bagshaw, P. F., Frampton, C. M., Frizelle, F. A., Hewett, P. J., Rieger, N. A., Smith, S., Solomon, M. J. and Stevenson, A. R. L. (2008), AUSTRALIAN AND NEW ZEALAND STUDY COMPARING LAPAROSCOPIC AND OPEN SURGERIES FOR COLON CANCER IN ADULTS: ORGANIZATION AND CONDUCT. ANZ Journal of Surgery, 78: 840–847. doi: 10.1111/j.1445-2197.2008.04678.x
The preparation of this article was overseen by the ALCCaS publications committee who assume responsibility for the overall content and integrity of the article.
- Issue published online: 8 OCT 2008
- Article first published online: 8 OCT 2008
- Accepted for publication 4 April 2008.
- colon cancer;
- colon surgery;
- laparoscopic colectomy;
- prospective randomized controlled trial
This article describes the initiation and implementation of the multicentre Australia and New Zealand prospective randomized controlled clinical study comparing laparoscopic and conventional open surgical treatments of right-sided and left-sided potentially curable colon cancer (Australasian Laparoscopic Colon Cancer Study). Six hundred and one adult patients were admitted with a clinical diagnosis of a single adenocarcinoma based on a physical examination and colonoscopy, barium enema or computed tomography scan and randomly allocated to either laparoscopic or open surgery. The primary aim of the study is to compare 5-year mortality and tumour recurrence rates between the two groups. Secondary aims include comparisons of safety (intraoperative and early postoperative complications, wound site recurrence, postoperative recovery and 30-day mortality), quality of life, in-hospital costs and short-term mortality and tumour recurrence. The data for 592 patients have been collected. There are currently 3141 person years of follow up. In all 370 patients have been assessed at 5 years. This study shows that large cooperative Australia–New Zealand surgical trials can and should be carried out to address significant clinical issues. When possible, coherence with similar, concurrent international trial protocols ensures broader analyses and applicability of results. It is important to recognize that special attention to sustained funding, surgeon credentialing, clinical protocol standardization, data management, publication policy and the protection of study credibility is required from the outset. The Australasian Laparoscopic Colon Cancer Study will achieve its aims with 5-year assessments of all entered patients in March 2010.