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REVIEW ARTICLE
Evolution of pancreas transplant surgery
Article first published online: 1 JUN 2010
DOI: 10.1111/j.1445-2197.2010.05309.x
© 2010 The Authors. Journal compilation © 2010 Royal Australasian College of Surgeons
Additional Information
How to Cite
Lam, V. W. T., Pleass, H. C. C., Hawthorne, W. and Allen, R. D. M. (2010), Evolution of pancreas transplant surgery. ANZ Journal of Surgery, 80: 411–418. doi: 10.1111/j.1445-2197.2010.05309.x
Publication History
- Issue published online: 1 JUN 2010
- Article first published online: 1 JUN 2010
- Accepted for publication 16 November 2009.
- Abstract
- Article
- References
- Cited By
Keywords:
- Pancreas Transplantation;
- Kidney Transplantation;
- Diabetes Mellitus
Abstract
Background: Type 1 diabetes mellitus is a chronic condition often leading to disabling complications including retinopathy, neuropathy and cardiovascular disease which can be modified by intensive treatment with insulin. Such treatment, however, is associated with a restrictive lifestyle and risk of hypoglycaemic morbidity and mortality.
Methods: This review examines the role of pancreas transplantation in patients with Type 1 diabetes mellitus.
Results: Pancreas transplantation is currently the only proven option to achieve long-term insulin independence, resulting in an improvement or stabilization of those diabetic related complications. The hazards of pancreas transplantation as a major operation are well known.
Balancing the risks of a surgical procedure, with the benefits of restoring normoglycaemia remains an important task for the pancreas transplant surgeon. Pancreas transplantation is not an emergency operation to treat poorly managed and non-compliant patients with debilitating complications. It is a highly specialized procedure which has evolved both in terms of the surgical technique, patient selection and assessment.
Conclusion: Pancreas transplantation has emerged as the single most effective way to achieve normal glucose homeostasis in patients with Type 1 diabetes mellitus.