D.-D. You MD; S.-H. Choi MD; D.-W. Choi MD; J.-S. Heo MD; C.-Y. Ho MD; W.-S. Kim MD.
Long-term effects of pancreaticoduodenectomy on glucose metabolism
Article first published online: 9 MAY 2012
© 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons
ANZ Journal of Surgery
Volume 82, Issue 6, pages 447–451, June 2012
How to Cite
You, D.-D., Choi, S.-H., Choi, D.-W., Heo, J.-S., Ho, C.-Y. and Kim, W.-S. (2012), Long-term effects of pancreaticoduodenectomy on glucose metabolism. ANZ Journal of Surgery, 82: 447–451. doi: 10.1111/j.1445-2197.2012.06080.x
- Issue published online: 3 JUN 2012
- Article first published online: 9 MAY 2012
- Accepted for publication 30 October 2011.
- pancreatogenic diabetes;
- post-operative diabetes
Background: To analyse the association between pancreatogenic diabetes and the volume of the remnant pancreas after pancreaticoduodenectomy and to identify clinicopathologic factors correlated with pancreatogenic diabetes.
Methods: Among the patients who underwent pancreaticoduodenenctomy from 2003 to 2004, 55 patients who survived by 2009 and were able to measure the volume of the pancreas pre- and post-operatively by CT volumetry were included in this study. Twelve patients had diabetes before surgery. Median follow-up duration was 55.2 and 67.3 months for CT volumetry, pancreatogenic diabetes, respectively.
Results: Among 43 patients without preoperative diabetes, nine patients (21%) developed newly diabetes after surgery. Among 12 patients with diabetes, 10 patients had worsened glucose control. The immediate post-operative Vol% was 46.5% and the last Vol% was 31.5% (P < 0.001). Preoperative diabetes, malignant pathology, absence of post-operative pancreatic fistula, chemotherapy and radiotherapy were correlated with a lower Vol%. Atrophic changes were observed in 29 patients and hypertrophic changes in 13 patients. Comparative analysis according to the change in the Vol% revealed no differences in the clinicopathological factors associated with new-onset pancreatogenic diabetes or aggravation of preoperative diabetes.
Conclusions: While some patients had a hypertrophic pancreas at the last follow-up, which reflected the capacity for pancreatic regeneration and some factors were associated with a lower volume of the remnant pancreas, the volume of the remnant pancreas seem not to be associated with pancreatogenic diabetes. There were no clinicopathologic factors identified associated with the risk for pancreatogenic diabetes.