These authors contributed equally to this work.
Usefulness of fluorodeoxyglucose positron emission tomography in malignancy of pulmonary artery mimicking pulmonary embolism
Article first published online: 3 SEP 2012
© 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons
ANZ Journal of Surgery
Volume 83, Issue 5, pages 342–347, May 2013
How to Cite
Lee, E. J., Moon, S. H., Choi, J. Y., Lee, K. S., Choi, Y. S., Choe, Y. S., Lee, K.-H. and Kim, B.-T. (2013), Usefulness of fluorodeoxyglucose positron emission tomography in malignancy of pulmonary artery mimicking pulmonary embolism. ANZ Journal of Surgery, 83: 342–347. doi: 10.1111/j.1445-2197.2012.06205.x
E. J. Lee MD; S. H. Moon MD; J. Y. Choi MD, PhD; K. S. Lee MD, PhD; Y. S. Choi MD, PhD; Y. S. Choe PhD; K.-H. Lee MD, PhD; B.-T. Kim MD, PhD.
- Issue published online: 24 APR 2013
- Article first published online: 3 SEP 2012
- Manuscript Accepted: 22 MAR 2012
- Samsung Biomedical Research Institute. Grant Number: #SBRI C-B0-320-1
- pulmonary artery sarcoma;
- pulmonary thromboembolism;
- tumour embolism
The role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in evaluating pulmonary artery lesions has not yet been established. The purpose of this study is to evaluate the usefulness of 18F-FDG PET/CT imaging in differentiating malignant from benign pulmonary artery (PA) lesions.
In this retrospective study, 18 subjects with 26 low-attenuated filling defects suspicious for PA malignancy on contrast-enhanced chest CT were enrolled; all of whom subsequently underwent 18F-FDG PET/CT. The maximum standardized uptake value (SUVmax) for all PA lesions, defined as the 18F-FDG uptake, was measured. The final diagnosis was then determined by pathological findings, follow-up chest CT or clinical follow-up, and compared with the PET imaging.
In total, 6 PA sarcomas, 5 tumour embolism, and 15 pulmonary thromboembolism (PTE) occurred in this cohort. Not only was the SUVmax of the malignant PA lesions (10.2 ± 10.8) was significantly higher than that associated with PTE (1.7 ± 0.3; P < 0.001), no overlap occurred between groups. Conversely, no statistically significant difference in SUVmax occurred between PA sarcomas (12.8 ± 14.7) and tumour embolism (7.0 ± 1.32; P = 1.000).
18F-FDG PET/CT is a useful imaging modality for differentiating malignant from benign PA lesions in patients with inconclusive low-attenuation filling defects on contrast-enhanced chest CT.