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Utility of 18-fluorodeoxyglucose positron emission/computed tomography in the management of recurrent colorectal cancer

Authors


  • S. Y. Liong MRCS, FRCR; R. Kochhar MD, FRCR; A. G. Renehan PhD, FRCR; P. Manoharan MRCP, FRCR.

Correspondence

Dr Prakash Manoharan, Department of Clinical Radiology, The Christie, Wilmslow Road, Manchester M20 4BX, UK. Email: prakash.manoharan@christie.nhs.uk

Abstract

Background

This study aimed to evaluate the utility of 18-fluorodeoxyglucose positron emission/computed tomography (PET/CT) in the management of colorectal cancer (CRC) patients with suspected recurrence.

Methods

Clinical and imaging histories of CRC patients who underwent PET/CT at our institution between 1 April 2007 and 31 August 2008 for evaluation of recurrent disease were retrospectively reviewed. Patients were divided into two groups – (A) patients evaluated for suspected local recurrence (based on conventional imaging) and (B) patients with carcinoembryonic antigen (CEA) levels in excess of 5 ng/mL; in whom conventional imaging was either normal or equivocal. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were derived using either histopathology or follow-up imaging as the standard of reference.

Results

In group A (n = 44), the sensitivity, specificity, PPV, NPV and accuracy of PET/CT were 100% (95% confidence interval (CI): 86.7–100), 84.2% (95% CI: 62.4–94.5), 89.3% (95% CI: 72.8–96.3), 100% (95% CI: 80.6–100) and 93.2%, respectively. In group B (n = 18), the sensitivity, specificity, PPV and NPV of PET/CT were 76.9% (95% CI: 49.7–91.8), 60.0%, (95% CI: 23.1–88.2), 83.3% (95% CI: 55.2–95.3) and 50% (95% CI: 18.8–81.2), respectively.

Conclusion

PET/CT has high accuracy in the assessment of local recurrence, particularly with regard to its NPV. PET/CT is useful for problem solving in cases of unexplained elevated CEA levels.

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