B. K. Ahn MD; K. H. Lee MD, PhD.
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Original Article
Single-dose antibiotic prophylaxis is effective enough in colorectal surgery
Article first published online: 5 SEP 2012
DOI: 10.1111/j.1445-2197.2012.06244.x
© 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons
Issue
ANZ Journal of Surgery
Early View (Online Version of Record published before inclusion in an issue)
Additional Information
How to Cite
Ahn, B. K. and Lee, K. H. (2012), Single-dose antibiotic prophylaxis is effective enough in colorectal surgery. ANZ Journal of Surgery. doi: 10.1111/j.1445-2197.2012.06244.x
This paper was presented as a poster at the annual autumn congress of the Korean Surgical Society, November 18–21, 2010, in Seoul, Korea.
Publication History
- Article first published online: 5 SEP 2012
- Manuscript Accepted: 30 JUN 2012
- Abstract
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Keywords:
- antibiotics;
- colorectal surgery;
- prophylaxis;
- surgical site infection
Abstract
Background
The aim of this study was to investigate the hypothesis that prevention of surgical site infection (SSI) is equally effective when patients receive single-dose (SD) or three-dose antibiotic prophylaxis with second-generation cephalosporin and metronidazole in elective colorectal surgery.
Methods
Ninety-three patients were enrolled from May 2009 to November 2010. The SD group received only one preoperative prophylactic intravenous dose and the three-dose or multiple-dose (MD) group received one preoperative prophylactic and two additional post-operative doses of second-generation cephalosporin and metronidazole. The incidence of infectious complications (SSI of the incision site and organ/space) was compared in the two groups.
Results
The overall post-operative infection rate did not differ between the two groups (16.7% in the SD versus 13.3% in the MD, P = 0.653). The incidence of SSI of the incision site and organ/space also did not differ between the groups (6.3% (3/48) versus 4.4% (2/45), P = 0.700; 4.2% versus 6.7%, P = 0.593, respectively). The number of antibiotics administered was not an independent risk factor for SSIs in multivariable analysis.
Conclusions
SD antibiotic prophylaxis with second-generation cephalosporin and metronidazole is equivalent to a three-dose prophylaxis for preventing SSI in elective colorectal surgery. But further study would be needed to clarify this because of the small number of participants.