S. D. Qi MBBS, BMedSci; P. D. Smith MBBS, PhD, FRACS; P. F. Choong MD, FRACS, FAOrthA.
Nuclear reprogramming and induced pluripotent stem cells: a review for surgeons
Version of Record online: 4 OCT 2012
© 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons
ANZ Journal of Surgery
Volume 84, Issue 6, pages E1–E11, June 2014
How to Cite
Qi, S. D., Smith, P. D. and Choong, P. F. (2014), Nuclear reprogramming and induced pluripotent stem cells: a review for surgeons. ANZ Journal of Surgery, 84: E1–E11. doi: 10.1111/j.1445-2197.2012.06282.x
- Issue online: 3 JUN 2014
- Version of Record online: 4 OCT 2012
- Manuscript Accepted: 27 AUG 2012
- induced pluripotent stem cell;
- nuclear reprogramming;
- regenerative medicine;
- stem cell
Induced pluripotent stem cells (iPSCs) are generated from somatic cells by the exogenous expression of defined transcription factors. iPSCs share the defining features of embryonic stem cells (ESCs) in that they are able to self-renew indefinitely and maintain the potential to develop into all cell types of the body. These cells have key advantages over ESCs in that they are autologous to the donor cells and can be generated from individuals at any age. iPSCs also circumvent ethical and political issues surrounding the destruction of embryos that is necessary in the isolation of ESCs. This review briefly describes the advent of iPSC technology and the concepts of nuclear reprogramming, and discusses the potential application of this powerful biological tool in both surgical research and regenerative medicine.