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Prognostic significance of tumour markers in Chinese patients with gastric cancer

Authors

  • Xiaowen Liu,

    1. Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai, China
    2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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  • Hong Cai,

    1. Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai, China
    2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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  • Yanong Wang

    Corresponding author
    1. Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai, China
    2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    • Correspondence

      Dr Yanong Wang, Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai 200032, China. Email: wangyn1111@hotmail.com

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  • X. Liu MD; H. Cai MD; Y. Wang MD.

Abstract

Background and objectives

The clinical value of preoperative tumour markers remains elusive in gastric cancer. The aim of this study was to investigate the prognostic value of alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen (CA)19-9, CA50 and CA72-4 in gastric cancer.

Methods

About 391 gastric cancer patients who underwent curative D2 gastrectomy between 2001 and 2006 were evaluated. The correlation between tumour markers and clinicopathologic characteristics and prognostic value of preoperative tumour markers was investigated.

Results

Correlation analysis showed that AFP was associated with tumour size (P = 0.040); CEA with lymphatic invasion (P = 0.023) and pathological stage (P = 0.018); CA19-9 with tumour size (P = 0.000), Borrmann type (P = 0.027), lymphatic invasion (P = 0.020) and pathological stage (P = 0.001); CA50 with lymphatic invasion (P = 0.004) and pathological stage (P = 0.004); CA72-4 with tumour size (P = 0.000), tumour size (P = 0.000) and Borrmann type (P = 0.008); lymphatic invasion (P = 0.000), nervous invasion (P = 0.028) and pathological stage (P = 0.000). Multivariate analysis showed that CEA, tumour site, Borrmann type and pathological stage were independent prognostic factors.

Conclusions

Preoperative CEA might be a candidate for the staging system in addition to conventional factors.

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