Whipple's Disease Involving the Pericardium: Pathological Confirmation During Life

Authors

  • R. E. Vlietstra,

    Corresponding author
    1. Departments of Internal Medicine, Pathology, and Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
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    • *Cardiologist.

  • J. T. Lie,

    1. Departments of Internal Medicine, Pathology, and Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
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    • †Cardiac Pathologist.

  • W. E. Kuhl,

    1. Departments of Internal Medicine, Pathology, and Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
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    • ‡Resident in Internal Medicine.

  • G. K. Danielson,

    1. Departments of Internal Medicine, Pathology, and Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
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    • **Cardiovascular Surgeon.

  • M. K. Roberts

    1. Departments of Internal Medicine, Pathology, and Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
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    • ††Electron -microscopist.


Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55901, USA

Abstract

Summary: Whipple's disease involving the pericardium: Pathological confirmation during life. R. E. Vlietstra, J. T. Lie, W. E. Kuhl, G. K. Danielson and M. K. Roberts, Aust. N.Z. J. Med., 1978, 8, pp. 649–651.

Cardiac involvement in Whipple's disease has been a frequent autopsy finding but is rarely recognized clinically. We report here a patient, a 63-year-old man, in whom Whipple's disease was diagnosed in 1974, based on a seven-year history of arthralgia, one-year history of weight loss and steatorrhea, and diagnostic small bowel biopsy. Despite complete regression of all joint and bowel symptoms following a prolonged course of tetracycline therapy, the patient developed incapacitating congestive heart failure and signs of constrictive pericarditis, for which a thoracotomy and pericardectomy was performed. Histologic examination revealed fibrous pericarditis with mononuclear infiltrates, including PAS-positive histiocytes. The characteristic bacilliform bodies were identified by electron microscopy in the resected pericardium. This to our knowledge is the first such demonstration during life of Whipple's disease involving the heart.

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