Risk estimates for drugs suspected of being associated with Stevens-Johnson syndrome and toxic epidermal necrolysis: a case-control study

  1. M.-S. Lin1,3,
  2. Y.-S. Dai2,
  3. R.-F. Pwu4,
  4. Y.-H. Chen2,
  5. N.-C. Chang5

Article first published online: 25 FEB 2005

DOI: 10.1111/j.1445-5994.2005.00790.x

Issue

Internal Medicine Journal

Internal Medicine Journal

Volume 35, Issue 3, pages 188–190, March 2005

Additional Information

How to Cite

Lin, M.-S., Dai, Y.-S., Pwu, R.-F., Chen, Y.-H. and Chang, N.-C. (2005), Risk estimates for drugs suspected of being associated with Stevens-Johnson syndrome and toxic epidermal necrolysis: a case-control study. Internal Medicine Journal, 35: 188–190. doi: 10.1111/j.1445-5994.2005.00790.x

Author Information

  1. 1

    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University

  2. 2

    Dermatology

  3. 3

    Pharmacy, National Taiwan University Hospital

  4. 4

    iSTAT Healthcare Consulting Co. Ltd

  5. 5

    Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan

*Correspondence to: Nen-Chung Chang, School of Medicine, Taipei Medical University Hospital. 252, Wu-Hsing Street, Taipei 105, Taiwan. Email: ncchang@tmu.edu.tw

Publication History

  1. Issue published online: 25 FEB 2005
  2. Article first published online: 25 FEB 2005
  3. Received 15 June 2004;accepted 30 October 2004.

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Keywords:

  • case-control study;
  • Stevens-Johnson syndrome;
  • toxic epidermal necrolysis;
  • adverse drug reaction;
  • relative risk

Abstract

The purpose of this case-control study is to estimate the risks of Stevens-Johnson syndrome or toxic epidermal necrolysis associated with the use of specific drugs. The suspected cases were identified from the computerized hospital discharge file. We calculated crude relative risks and adjusted them for confounding by multivariate analysis. The analysis was based on 35 cases and 105 controls. This study showed that the use of carbamazepine, phenytoin and allopurinol is most associated with the risks in the oriental population. (Intern Med J 2005; 35: 188–190)

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