Close correlation between chronic sclerosing sialadenitis and immunoglobulin G4
Version of Record online: 7 JUL 2006
2006 Royal Australasian College of Physicians
Internal Medicine Journal
Volume 36, Issue 8, pages 527–529, August 2006
How to Cite
Kamisawa, T., Nakajima, H. and Hishima, T. (2006), Close correlation between chronic sclerosing sialadenitis and immunoglobulin G4. Internal Medicine Journal, 36: 527–529. doi: 10.1111/j.1445-5994.2006.01119.x
Potential conflicts of interest: None
- Issue online: 7 JUL 2006
- Version of Record online: 7 JUL 2006
- Received 15 July 2005; accepted 20 October 2005.
- chronic sclerosing sialadenitis;
- immunoglobulin G4;
- autoimmune pancreatitis
In four patients with chronic sclerosing sialadenitis, serum immunoglobulin G4 concentration was markedly increased and abundant infiltration of immunoglobulin G4-positive plasma cells was observed in the salivary glands. Autoimmune pancreatitis occurred in the two patients during follow up. Chronic sclerosing sialadenitis and autoimmune pancreatitis would appear to show essentially the same pathophysiological mechanism. Measurement of serum immunoglobulin G4 concentration is useful in differentiating chronic sclerosing sialadenitis from neoplasia.