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Close correlation between chronic sclerosing sialadenitis and immunoglobulin G4


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    Potential conflicts of interest: None

Terumi Kamisawa, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan.


In four patients with chronic sclerosing sialadenitis, serum immunoglobulin G4 concentration was markedly increased and abundant infiltration of immunoglobulin G4-positive plasma cells was observed in the salivary glands. Autoimmune pancreatitis occurred in the two patients during follow up. Chronic sclerosing sialadenitis and autoimmune pancreatitis would appear to show essentially the same pathophysiological mechanism. Measurement of serum immunoglobulin G4 concentration is useful in differentiating chronic sclerosing sialadenitis from neoplasia.