Clostridium difficile-associated diarrhoea
Article first published online: 19 JUL 2007
Internal Medicine Journal
Volume 37, Issue 8, pages 561–568, August 2007
How to Cite
Elliott, B., Chang, B. J., Golledge, C. L. and Riley, T. V. (2007), Clostridium difficile-associated diarrhoea. Internal Medicine Journal, 37: 561–568. doi: 10.1111/j.1445-5994.2007.01403.x
Potential conflicts of interest: None
- Issue published online: 19 JUL 2007
- Article first published online: 19 JUL 2007
- Received 13 December 2006; accepted 7 March 2007.
- Clostridium difficile;
- epidemic strain;
- antibiotic resistance;
Clostridium difficile is an important nosocomial pathogen and the most frequently diagnosed cause of infectious hospital-acquired diarrhoea. Toxigenic strains usually produce toxin A and toxin B, which are the primary virulence factors of C. difficile. Some recently described strains produce an additional toxin, an adenosine-diphosphate ribosyltransferase known as binary toxin, the role of which in pathogenicity is unknown. There has been concern about the emergence of a hypervirulent fluoroquinolone-resistant strain of C. difficile in North America and Europe. The use of fluoroquinolone antimicrobials appears to be acting as a selective pressure in the emergence of this strain. In this review, we describe the current state of knowledge about C. difficile as a cause of diarrhoeal illness.