Funding: This study was funded by a project grant from the National Health and Medical Research Council of Australia (project number: 403996). The funding agency had no role in the design, analysis or drafting of the results of this study. Griselda J. Garrido is partly supported by the Fundação de Amparo à pesquisa do Estado de São Paulo (FAPESP project grant 03/11794-6).
Coronary heart disease is associated with regional grey matter volume loss: implications for cognitive function and behaviour
Article first published online: 15 JUL 2008
© 2008 The Authors Journal compilation © 2008 Royal Australasian College of Physicians
Internal Medicine Journal
Volume 38, Issue 7, pages 599–606, July 2008
How to Cite
Almeida, O. P., Garrido, G. J., Beer, C., Lautenschlager, N. T., Arnolda, L., Lenzo, N. P., Campbell, A. and Flicker, L. (2008), Coronary heart disease is associated with regional grey matter volume loss: implications for cognitive function and behaviour. Internal Medicine Journal, 38: 599–606. doi: 10.1111/j.1445-5994.2008.01713.x
Potential conflicts of interest: None
- Issue published online: 15 JUL 2008
- Article first published online: 15 JUL 2008
- Received 27 July 2007; accepted 10 November 2007.
- coronary heart disease;
- grey matter;
- cognitive function;
- brain imaging;
Coronary heart disease (CHD) has been associated with impaired cognition, but the mechanisms underlying these changes remain unclear. We designed this study to determine whether adults with CHD show regional brain losses of grey matter volume relative to controls. We used statistical parametric mapping (SPM5) to determine regional changes in grey matter volume of T1-weighted magnetic resonance images of 11 adults with prior history of myocardial infarction relative to seven healthy controls. All analyses were adjusted for total grey and white matter volume, age, sex and handedness. CHD participants showed a loss of grey matter volume in the left medial frontal lobe (including the cingulate), precentral and postcentral cortex, right temporal lobe and left middle temporal gyrus, and left precuneus and posterior cingulate. CHD is associated with loss of grey matter in various brain regions, including some that play a significant role in cognitive function and behaviour. The underlying causes of these regional brain changes remain to be determined.