Funding: Dr Ziegelstein is supported by grant number R24AT004641 from the National Center for Complementary and Alternative Medicine and by the Miller Family Scholar Programme.
Platelet function in patients with major depression
Article first published online: 15 AUG 2008
© 2009 The Authors Journal compilation © 2009 Royal Australasian College of Physicians
Internal Medicine Journal
Volume 39, Issue 1, pages 38–43, January 2009
How to Cite
Ziegelstein, R. C., Parakh, K., Sakhuja, A. and Bhat, U. (2009), Platelet function in patients with major depression. Internal Medicine Journal, 39: 38–43. doi: 10.1111/j.1445-5994.2008.01794.x
Potential conflicts of interest: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Complementary & Alternative Medicine or the National Institutes of Health.
- Issue published online: 5 MAR 2009
- Article first published online: 15 AUG 2008
- Received 8 December 2007; accepted 24 June 2008.
- cardiovascular disease;
- selective serotonin re-uptake inhibitors
Depression, ischaemic heart disease and cerebrovascular disease are important causes of morbidity and are among the leading contributors to global health burden. These conditions often occur in the same patient, resulting in considerably greater effect on health than combinations of chronic diseases without depression. The frequent occurrence of these conditions in the same patient raises the possibility of a common genetic predisposition, similar risk factors or a pathophysiological link. Serotoninergic and adrenergic signalling play important roles in causing major depression and also in platelet activation and aggregation, which underlies vascular disease. This review discusses the potential pathophysiological link between major depression and conditions in which platelet activation plays an important role and also provides evidence linking the use of the most commonly used antidepressant drugs (i.e. the selective serotonin re-uptake inhibitors) to increased risk of bleeding.