Prevalence of hepatitis B virus infection in non-Hodgkin lymphoma: a systematic review and meta-analysis
Version of Record online: 15 SEP 2010
© 2010 The Authors. Internal Medicine Journal © 2010 Royal Australasian College of Physicians
Internal Medicine Journal
Volume 40, Issue 9, pages 633–641, September 2010
How to Cite
Nath, A., Agarwal, R., Malhotra, P. and Varma, S. (2010), Prevalence of hepatitis B virus infection in non-Hodgkin lymphoma: a systematic review and meta-analysis. Internal Medicine Journal, 40: 633–641. doi: 10.1111/j.1445-5994.2009.02060.x
Conflict of interest: None.
- Issue online: 15 SEP 2010
- Version of Record online: 15 SEP 2010
- Received 2 February 2009; accepted 31 May 2009.
- hepatitis B virus;
- non-Hodgkin lymphoma;
Background and aim: A recent meta-analysis has demonstrated an association between hepatitis C virus and non-Hodgkin lymphoma (NHL). There is also evidence on the association between hepatitis B virus (HBV) and NHL. The aim of this study was to evaluate this evidence using a meta-analytic approach.
Methods: We searched the MEDLINE database from 1962 to 2008 for case–control studies that have reported the association of HBV with NHL. We calculated the odds ratio (OR) and 95% confidence intervals (CI) to assess the prevalence of HBV infection and pooled the results using three different statistical models.
Results: Our search yielded 12 studies with 11 studies (3262 NHL patients, 1 523 205 controls) evaluating HBV infection in NHL and one study (3888 HBV-infected individuals, 205 203 controls) that had investigated for NHL in HBV infection. The OR of detecting HBV infection in NHL when compared with the control population was 2.56 (95% CI, 2.24–2.92) by the fixed effects model; 2.61 (95% CI, 2.29–2.98) by the exact method and 2.67 (95% CI, 2.04–3.49) by the random effects model suggesting a high prevalence of HBV carrier state in lymphoma. There was evidence of statistical heterogeneity which disappeared after exclusion of retrospective studies on sensitivity analysis.
Conclusions: The results of this study suggest a possible causal relation between HBV infection and NHL which needs to be confirmed by experimental and epidemiological studies. In countries where prevalence of HBV infection is 1% or more, it may be prudent to screen patients with NHL for occult HBV infection.