Funding: This study was supported by grants from the Swiss Cardiology Foundation and Cardiomet-CHUV.
Hypertension is an independent predictor of mean platelet volume in patients with acute ischaemic stroke
Article first published online: 8 SEP 2011
© 2011 The Authors. Internal Medicine Journal © 2011 Royal Australasian College of Physicians
Internal Medicine Journal
Volume 41, Issue 9, pages 691–695, September 2011
How to Cite
Ntaios, G., Gurer, O., Faouzi, M., Aubert, C. and Michel, P. (2011), Hypertension is an independent predictor of mean platelet volume in patients with acute ischaemic stroke. Internal Medicine Journal, 41: 691–695. doi: 10.1111/j.1445-5994.2009.02162.x
Conflict of interest: None.
- Issue published online: 8 SEP 2011
- Article first published online: 8 SEP 2011
- Received 16 June 2009; accepted 3 November 2009.
- mean platelet volume;
- acute ischaemic stroke
Introduction: Mean platelet volume (MPV) was shown to be significantly increased in patients with acute ischaemic stroke, especially in non-lacunar strokes. Moreover, some studies concluded that increased MPV is related to poor functional outcome after ischaemic stroke, although this association is still controversial. However, the determinants of MPV in patients with acute ischaemic stroke have never been investigated.
Subjects and methods: We recorded the main demographic, clinical and laboratory data of consecutive patients with acute (admitted within 24 h after stroke onset) ischaemic stroke admitted in our Neurology Service between January 2003 and December 2008. MPV was generated at admission by the Sysmex XE-2100 automated cell counter (Sysmex Corporation, Kobe, Japan) from ethylenediaminetetraacetic acid blood samples stored at room temperature until measurement. The association of these parameters with MPV was investigated in univariate and multivariate analysis.
Results: A total of 636 patients was included in our study. The median MPV was 10.4 ± 0.82 fL. In univariate analysis, glucose (β= 0.03, P= 0.05), serum creatinine (β= 0.002, P= 0.02), haemoglobin (β= 0.009, P < 0.001), platelet count (β=−0.002, P < 0.001) and history of arterial hypertension (β= 0.21, P= 0.005) were found to be significantly associated with MPV. In multivariate robust regression analysis, only hypertension and platelet count remained as independent determinants of MPV.
Conclusions: In patients with acute ischaemic stroke, platelet count and history of hypertension are the only determinants of MPV.