Funding: This study was supported in whole by a research grant from GlaxoSmithKline (GSK).
Childhood asthma and GOLD-defined chronic obstructive pulmonary disease
Article first published online: 12 APR 2010
© 2010 The Authors. Internal Medicine Journal © 2010 Royal Australasian College of Physicians
Internal Medicine Journal
Volume 42, Issue 1, pages 83–88, January 2012
How to Cite
Shirtcliffe, P., Marsh, S., Travers, J., Weatherall, M. and Beasley, R. (2012), Childhood asthma and GOLD-defined chronic obstructive pulmonary disease. Internal Medicine Journal, 42: 83–88. doi: 10.1111/j.1445-5994.2010.02238.x
Conflict of interest: GSK did not undertake any analysis or contribute to the writing of the manuscript. The authors did not receive any monetary reward from GSK and had editorial freedom with respect to the manuscript.
- Issue published online: 12 APR 2010
- Article first published online: 12 APR 2010
- Accepted manuscript online: 4 AUG 2010 12:07PM EST
- Received 23 November 2009; accepted 20 March 2010.
- risk factor
Background: Current understanding of chronic obstructive pulmonary disease (COPD) is that it results from an interaction of genetic and environmental factors. This study aimed to investigate the strength of association of various known risk factors for COPD.
Methods: Detailed written questionnaires, full pulmonary function tests and atopy testing were completed in 749 people, aged 25–75 years, recruited from a random population sample. COPD was defined, using Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, as a post-bronchodilator forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) ratio <0.7.
Results: The prevalence of COPD was higher in men (OR 1.7 (95% CI 1.1–2.7)) and increased with increasing age (OR per decade older 2.1 (95% CI 1.7–2.7)). COPD was more frequent in current and ex-smokers and increased with increasing pack years (OR per 10 pack years 1.3 (95% CI 1.1–1.5)). On a logit scale, a diagnosis of asthma as a child conferred a similar risk as an increase in age of 22 years or 62 pack years of cigarette smoking.
Conclusion: Childhood asthma emerged with the strongest association for GOLD-defined COPD. Possible explanations for this are suggested, including limitations of the current GOLD spirometric definition of COPD, a chance observation because of the high prevalence of both disorders in this population, or alternatively childhood asthma is a risk factor for COPD.