Menstrual cycle variation of retroperitoneal lymphangioleiomyomas in lymphangioleiomyomatosis
Article first published online: 8 DEC 2011
© 2011 The Authors. Internal Medicine Journal © 2011 Royal Australasian College of Physicians
Internal Medicine Journal
Volume 41, Issue 12, pages 832–835, December 2011
How to Cite
Sandrini, A., Silverstone, E. and Yates, D. H. (2011), Menstrual cycle variation of retroperitoneal lymphangioleiomyomas in lymphangioleiomyomatosis. Internal Medicine Journal, 41: 832–835. doi: 10.1111/j.1445-5994.2011.02593.x
Conflict of interest: None.
- Issue published online: 8 DEC 2011
- Article first published online: 8 DEC 2011
- Received 3 May 2010; accepted 23 August 2010.
- abdominal lymphangioleiomyoma;
- female sex hormones
Lymphangioleiomyomatosis (LAM) is a rare disease affecting women, classically involving the lungs. However, extrapulmonary manifestations also occur, including renal angiomyolipomas, retroperitoneal lymphangioleiomyomas and extrathoracic lymphadenopathy. The lung disease is hormone-responsive, but no information exists regarding sex hormone responsiveness of abdominal LAM. Here, we report two women with LAM whose abdominal lymphangioleiomyomas increased in size with hormonal changes of the menstrual cycle. This is the first description of abdominal lymphangioleiomyomas exhibiting hormone responsiveness in LAM. We describe these cases and summarize the literature on abdominal LAM. Menstrual cycle variation should be taken into account when assessing response to therapy, both clinically and in research studies.