Principles, current status and clinical implications of ischaemic heart disease assessment by cardiac magnetic resonance imaging

Authors

  • W. Chan,

    1. BakerIDI Heart and Diabetes Institute
    2. Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    3. Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, Toronto, Ontario, Canada
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  • A. H. Ellims,

    1. Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia
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  • S. J. Duffy,

    1. BakerIDI Heart and Diabetes Institute
    2. Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia
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  • D. M. Kaye,

    1. BakerIDI Heart and Diabetes Institute
    2. Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia
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  • A. J. Taylor

    Corresponding author
    1. BakerIDI Heart and Diabetes Institute
    2. Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia
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  • Funding: W.C. is supported by a postgraduate scholarship from the National Health and Medical Research Council of Australia and a support grant from GlaxoSmithKline Australia. A.J.T. is supported by the National Health and Medical Research Council Program Grant and the National Heart Foundation Grant, Melbourne, Australia.

  • Conflict of interest: None.

Andrew J. Taylor, Heart Centre, The Alfred Hospital, 3rd Floor, W.S. Philip Block, Commercial Road, Melbourne, Vic. 3004, Australia. Email: andrew.taylor@bakeridi.edu.au

Abstract

Cardiac magnetic resonance imaging (CMR) has matured into a robust, accurate and highly reproducible imaging modality for the assessment of cardiac function and ischaemic heart disease. The unique physical properties of CMR permit depiction of pathology-specific tissue contrast based on differences in tissue composition, such as myocardial oedema, necrosis and fibrosis. This can be imaged at high spatial resolution allowing characterisation of the acuity of an ischaemic event, the presence and extent of myocardial ischaemia, necrosis and viability. Prognostically important information obtained from CMR evaluation of ischaemic heart disease, such as left ventricular ejection fraction, infarct size and transmurality, infarct location and the presence of intraventricular mechanical dyssynchrony may be used to guide coronary revascularisation, device and medical therapies.

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