Survival responses to oxidative stress and aging
Version of Record online: 2 JUN 2010
© 2010 Japan Geriatrics Society
Geriatrics & Gerontology International
Special Issue: Gerontology and Geriatrics Science: Gene to Longevity
Volume 10, Issue Supplement s1, pages S1–S9, July 2010
How to Cite
Miura, Y. and Endo, T. (2010), Survival responses to oxidative stress and aging. Geriatrics & Gerontology International, 10: S1–S9. doi: 10.1111/j.1447-0594.2010.00597.x
- Issue online: 2 JUN 2010
- Version of Record online: 2 JUN 2010
- Accepted for publication 20 November 2009.
- adaptive response;
- ataxia telangiectasia mutated;
- DNA repair;
- oxidative stress;
Oxidative stress is recognized as an important environmental factor in aging; however, because reactive oxygen species (ROS) and related free radicals are normally produced both intra- and extracellularly, air-living organisms cannot avoid the risk of oxidative stress. Consequently, these organisms have evolved various anti-oxidant systems to prevent ROS, scavenge free radicals, repair damaged components and adaptive responses. This review will focus on the repair and adaptive response to oxidative stress, and summarize the changes of these systems as a result aging and their relationship to premature aging. Geriatr Gerontol Int 2010; 10 (Suppl. 1): S1–S9.