Alteration of brain glycoproteins during aging
Article first published online: 2 JUN 2010
© 2010 Japan Geriatrics Society
Geriatrics & Gerontology International
Special Issue: Gerontology and Geriatrics Science: Gene to Longevity
Volume 10, Issue Supplement s1, pages S32–S40, July 2010
How to Cite
Sato, Y. and Endo, T. (2010), Alteration of brain glycoproteins during aging. Geriatrics & Gerontology International, 10: S32–S40. doi: 10.1111/j.1447-0594.2010.00602.x
- Issue published online: 2 JUN 2010
- Article first published online: 2 JUN 2010
- Accepted for publication 20 November 2009.
- brain glycoprotein;
Glycosylation is the most common post-translational modification of proteins. Protein sequence data suggested that more than half of all proteins produced in mammalian cells are glycoproteins. Recent studies showed that glycans of secreted glycoproteins affect many protein properties, such as solubility, stability, protease sensitivity and polarity, whereas glycans on cell-surface glycoproteins are involved in various cellular functions, including cell–cell communication. Accordingly, the investigation of glycoprotein changes caused by aging is expected to help understand the aging process and to elucidate age-associated diseases. The present review will summarize our current knowledge of changes found in brain glycoproteins resulting from the aging process. Geriatr Gerontol Int 2010; 10 (Suppl. 1): S32–S40.