ORIGINAL ARTICLE: EPIDEMIOLOGY, CLINICAL PRACTICE AND HEALTH
Multimodal exercise intervention improves frontal cognitive functions and gait in Alzheimer's disease: A controlled trial
Version of Record online: 11 JUN 2012
© 2012 Japan Geriatrics Society
Geriatrics & Gerontology International
Volume 13, Issue 1, pages 198–203, January 2013
How to Cite
Coelho, F. G. d. M., Andrade, L. P., Pedroso, R. V., Santos-Galduroz, R. F., Gobbi, S., Costa, J. L. R. and Gobbi, L. T. B. (2013), Multimodal exercise intervention improves frontal cognitive functions and gait in Alzheimer's disease: A controlled trial. Geriatrics & Gerontology International, 13: 198–203. doi: 10.1111/j.1447-0594.2012.00887.x
- Issue online: 3 JAN 2013
- Version of Record online: 11 JUN 2012
- Accepted for publication 19 April 2012.
- Alzheimer dementia;
- cognitive decline;
- dual task;
- gait disorders;
- non-pharmacological therapy
Aim: The objective of the present study was to investigate the effect of a multimodal exercise intervention on frontal cognitive functions and kinematic gait parameters in patients with Alzheimer's disease.
Methods: A sample of elderly patients with Alzheimer's disease (n = 27) were assigned to a training group (n = 14; aged 78.0 ± 7.3 years) and a control group (n = 13; aged 77.1 ± 7.4 years). Multimodal exercise intervention includes motor activities and cognitive tasks simultaneously. The participants attended a 1-h session three times a week for 16 weeks, and the control participants maintained their regular daily activities during the same period. The frontal cognitive functions were evaluated using the Frontal Assessment Battery, the Clock Drawing Test and the Symbol Search Subtest. The kinematic parameters of gait-cadence, stride length and stride speed were analyzed under two conditions: (i) free gait (single task); and (ii) gait with frontal cognitive task (walking and counting down from 20 – dual task).
Results and discussion: The patients in the intervention group significantly increased the scores in frontal cognitive variables, Frontal Assessment Battery (P < 0.001) and Symbol Search Subtest (P < 0.001) after the 16-week period. The control group decreased the scores in the Clock Drawing Test (P = 0.001) and increased the number of counting errors during the dual task (P = 0.008) after the same period.
Conclusion: The multimodal exercise intervention improved the frontal cognitive functions in patients with Alzheimer's disease. Geriatr Gerontol Int 2013; 13: 198–203.