Inhibin-producing ovarian granulosa cell tumor as a cause of secondary amenorrhea: Case report and review of the literature
Article first published online: 17 NOV 2004
Journal of Obstetrics and Gynaecology Research
Volume 30, Issue 6, pages 439–443, December 2004
How to Cite
Kurihara, S., Hirakawa, T., Amada, S., Ariyoshi, K. and Nakano, H. (2004), Inhibin-producing ovarian granulosa cell tumor as a cause of secondary amenorrhea: Case report and review of the literature. Journal of Obstetrics and Gynaecology Research, 30: 439–443. doi: 10.1111/j.1447-0756.2004.00231.x
- Issue published online: 17 NOV 2004
- Article first published online: 17 NOV 2004
- Received: April 9 2004. Accepted: September 6 2004.
- follicle-stimulating hormone;
- granulosa cell tumor;
- secondary amenorrhea
We report the case of 31-year-old patient with an inhibin B-secreting granulosa cell tumor of the left ovary who presented with secondary amenorrhea. Preoperative serum hormonal levels were as follows: follicle-stimulating hormone (FSH) 0.3 mIU/mL, luteinizing hormone (LH) 9.81 mIU/mL, estradiol 142.0 pg/mL and inhibin B 2429 pg/mL. Gonadotropin-releasing hormone (GnRH) test revealed no FSH response and a normal LH response. After removal of the tumor, the levels of FSH and inhibin B returned to within the normal range, and regular menses resumed 27 days postoperatively. In premenopausal women, secondary amenorrhea may be the initial manifestation of granulosa cell tumor. A low FSH level coupled with normal levels of E2 and LH, the inhibition of the FSH response to GnRH and an elevated inhibin level suggest the presence of an inhibin-secreting ovarian tumor and also rule out the possibility of isolated FSH deficiency.