Single inherited thrombophilias and adverse pregnancy outcomes
Article first published online: 6 AUG 2007
Journal of Obstetrics and Gynaecology Research
Volume 33, Issue 4, pages 423–430, August 2007
How to Cite
Larciprete, G., Gioia, S., Angelucci, P. A., Brosio, F., Barbati, G., Angelucci, G. P., Frigo, M. G., Baiocco, F., Romanini, M. E., Arduini, D. and Cirese, E. (2007), Single inherited thrombophilias and adverse pregnancy outcomes. Journal of Obstetrics and Gynaecology Research, 33: 423–430. doi: 10.1111/j.1447-0756.2007.00550.x
- Issue published online: 6 AUG 2007
- Article first published online: 6 AUG 2007
- Received: February 5 2006.Accepted: October 31 2006.
Introduction: Inherited thrombophilia is believed to be a multiple gene disease with more than one defect. We aimed to determine the association between single thrombophilic patterns and a variety of pregnancy diseases.
Methods: 284 pregnant women were recruited for the present study and were divided in two groups: A group (176 controls) and B group (108 cases). Patients belonging to the B group had one of the following: severe pre-eclampsia, hemolysis, hepatic enzymes increase, hypertension and low platelet count (HELLP) syndrome, gestational hypertension, fetal growth restriction, intrauterine death, abruptio placentae and disseminated intravascular coagulopathy. To detect methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, factor V Leiden, PAI-1, mutant prothrombin G20210A, an inverse hybridization technology was used. Plasma homocysteine, antithrombin (AT) III and protein S were determined. A modified functional activated protein C resistance was detected.
Results: MTHFR C677T and hyperhomocysteinemia were more prevalent than other thrombophilias. Deficiency in AT III was significantly linked with pre-eclampsia (relative risk 0.88; 95% CI 0.83–0.94). Activated protein C resistance (APCR) was significantly related to the abruptio placentae (relative risk 0.71; 95% CI 0.61–0.82).
Comments: Apart from the linkage between AT III deficiency and the occurrence of pre-eclampsia, and apart from the increased risk of abruptio placentae in pregnant women with altered APCR, we obtained findings in contrast with some of the published literature. In our case series, no association of pre-eclampsia with factor V Leiden or with prothrombin gene mutation was found.