Recurrent pregnancy loss: A disease of inflammation and coagulation
Article first published online: 24 AUG 2009
© 2009 The Authors. Journal compilation © 2009 Japan Society of Obstetrics and Gynecology
Journal of Obstetrics and Gynaecology Research
Volume 35, Issue 4, pages 609–622, August 2009
How to Cite
Kwak-Kim, J., Yang, K. M. and Gilman-Sachs, A. (2009), Recurrent pregnancy loss: A disease of inflammation and coagulation. Journal of Obstetrics and Gynaecology Research, 35: 609–622. doi: 10.1111/j.1447-0756.2009.01079.x
- Issue published online: 8 SEP 2009
- Article first published online: 24 AUG 2009
- Received: March 9 2009.Accepted: April 13 2009.
- NK cells;
- recurrent pregnancy loss;
- Th1 immune response;
Recurrent pregnancy loss (RPL) is one of the most common obstetrical complications. Multiple etiologies, such as endocrine, anatomic, genetic, hematological and immunological causes have been reported for this devastating disease. However, over half of the cases remain unexplained. Thrombotic/inflammatory processes are often observed at the maternal-fetal interface as the final pathological assault in many cases of RPL, including those of unexplained etiologies. In the present paper, cellular immune responses (T, natural killer [NK], natural killer-T [NKT], regulatory T [Treg] cells and their cytokines) and autoimmune abnormalities of women with RPL are reviewed. In addition, metabolic diseases and hematological conditions which often lead to thrombotic/inflammatory conditions are discussed in association with RPL. Finally, current therapeutic options for RPL are reviewed.