Get access

Antioxidant supplementation in pregnant women with low antioxidant status

Authors

  • Noroyono Wibowo,

    1. Department of Obstetrics and Gynecology, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
    Search for more papers by this author
  • Yuditiya Purwosunu,

    Corresponding author
    1. Department of Obstetrics and Gynecology, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
    2. Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan
    3. Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Denmark Hill, London, UK
      Dr Yuditiya Purwosunu, Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Denmark Hill, London, SE5 9RS, UK. Email: yudi@med.showa-u.ac.jp
    Search for more papers by this author
  • Akihiko Sekizawa,

    1. Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan
    Search for more papers by this author
  • Antonio Farina,

    1. Department of Obstetrics and Gynecology, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
    2. Department of Histology and Embryology Division of Prenatal Medicine, University of Bologna, Bologna, Italy
    Search for more papers by this author
  • Liana Idriansyah,

    1. Department of Obstetrics and Gynecology, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
    Search for more papers by this author
  • Ika Fitriana

    1. Department of Obstetrics and Gynecology, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
    Search for more papers by this author

Dr Yuditiya Purwosunu, Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Denmark Hill, London, SE5 9RS, UK. Email: yudi@med.showa-u.ac.jp

Abstract

Aim:  The aim of this study was to investigate the benefit of antioxidant supplementation in a cohort of women with low antioxidant status and determine the changes in cell-free mRNA.

Material and Methods:  This study was a randomized, placebo-controlled trial of 8–12 weeks' pregnant women who had low antioxidant status treated with either antioxidants or control diets daily until 2 weeks' postpartum. The primary end-point was the risk of pre-eclampsia and the secondary end-point was the changes of angiogenic and anti-oxidant mRNA markers related to the outcome (ClinicalTrial.gov, number NCT01232205).

Results:  There were 110 women enrolled in the study, randomly assigned to the supplementation (n = 52) and control group (n = 58). The overall rate of pre-eclampsia was 8.7% (nine subjects). There were significant differences (P = 0.034) between the supplementation and control group in the incidence of pre-eclampsia (2.0% [one case] and 14.5% [eight cases], respectively) and mRNA level of superoxide-dismutase, heme oxygenase-1, vascular endothelial growth factor receptor-1, endoglin and placental growth factor after supplementation.

Conclusion:  Supplementation of women with low antioxidant status with micronutrients containing antioxidants during early gestation might reduce the risk of pre-eclampsia.

Get access to the full text of this article

Ancillary