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Granulosa cell tumor of the ovary after long-term use of tamoxifen and toremifene

Authors


Dr Tomohito Tanaka, Department of Obstetrics and Gynecology, Osaka Minami Medical Center, 2-1, Kidohigashi-machi, Kawachinagano, Osaka 586-8521, Japan. Email: tomohito@ommc-hp.jp

Abstract

The relation between the use of tamoxifen and gynecologic tumors has been documented. In this case, a 58-year-old postmenopausal woman had been treated with tamoxifen for 5 years followed by toremifene for 1.5 years due to the presence of stage II estrogen receptor-positive breast cancer. The patient was found to have a stage Ic granulosa cell tumor of the ovary despite undergoing annual gynecologic examinations. This report presents a case of granulosa cell tumor of the ovary after the long-term use of tamoxifen and toremifene.

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