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Keywords:

  • amniotic fluid;
  • erythropoietin;
  • hepcidin;
  • meconium passage

Abstract

Aim:  To compare hepcidin and erythropoietin levels in the cord blood of neonates with meconium-stained amniotic fluid (MSAF) to levels obtained from age-, body mass index- and gravidity-matched neonates with clear amniotic fluid.

Methods:  A cross-sectional controlled study was conducted in secondary and tertiary care centers. Cord blood samples of 40 neonates following term gestations (≥37 weeks' gestation) with MSAF and 40 maternal age-, body mass index- and gravidity-matched controls with clear amniotic fluid were analyzed in this study. Demographic data, delivery outcomes and laboratory evaluations were recorded.

Results:  Cord blood pH levels were lower in fetuses with MSAF when compared to those with clear amniotic fluid (P = 0.0001). Fetuses with MSAF had higher cord blood erythropoietin levels in comparison to those with clear amniotic fluid (P = 0.0001). Delivery outcomes and hepcidin measurements were similar in both groups.

Conclusions:  We demonstrated a significant relationship between erythropoietin levels and meconium passage, but failed to show the existence of a relationship between hepcidin levels and meconium passage.