Metastatic adenocarcinoma of mammary-like glands of the vulva successfully treated with surgery and hormonal therapy
Article first published online: 6 JUL 2012
© 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology
Journal of Obstetrics and Gynaecology Research
Volume 39, Issue 1, pages 450–454, January 2013
How to Cite
Benito, V., Arribas, S., Martínez, D., Medina, N., Lubrano, A. and Arencibia, O. (2013), Metastatic adenocarcinoma of mammary-like glands of the vulva successfully treated with surgery and hormonal therapy. Journal of Obstetrics and Gynaecology Research, 39: 450–454. doi: 10.1111/j.1447-0756.2012.01937.x
- Issue published online: 7 JAN 2013
- Article first published online: 6 JUL 2012
- Received: September 17 2011.; Accepted: April 14 2012.
- mammary-like glands;
- vulvar cancer
Vulvar cancer is a rare malignancy; most tumors are squamous cell type while adenocarcinomas are rare. Primary adenocarcinomas of the vulva predominantly include extramammary Paget's disease and sweat gland carcinomas. Greene first described a rare form of adenocarcinoma in 1936, which was called adenocarcinoma of mammary-like glands of the vulva because of its morphologic and immunohistochemical resemblance to breast adenocarcinomas. In the management of this entity, varying combinations of surgery, radiation therapy, systemic chemotherapy and/or hormonal therapy may be used, as in patients with orthotopic breast carcinoma. However, hormonal therapy leads the way in patients with positive hormonal receptors, where other therapies cannot be used due to comorbidities or advanced age. We present the first reported case of an elderly patient with metastatic vulvar adenocarcinoma arising from mammary-like glands, successfully treated with a combination of surgery and hormonal therapy.