TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology
Article first published online: 6 JUL 2012
© 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology
Journal of Obstetrics and Gynaecology Research
Volume 39, Issue 1, pages 237–242, January 2013
How to Cite
Ozbek, E., Polat, E. C., Ozcan, L., Otunctemur, A., Emrence, Z. and Ustek, D. (2013), TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology. Journal of Obstetrics and Gynaecology Research, 39: 237–242. doi: 10.1111/j.1447-0756.2012.01942.x
- Issue published online: 7 JAN 2013
- Article first published online: 6 JUL 2012
- Received: December 27 2011.; Accepted: April 14 2012.
- lysyl oxidase like-1;
- stress urinary incontinence
Aim: In experimental studies, lysyl oxidase like-1 (LOX-L1) (−/−) mice were shown to have similar pelvic floor dysfunction to female rats. LOX-L1 levels in endopelvic fascia decrease as a result of increasing births in women with pelvic prolapse. For these reasons, we investigated the LOX-L1 gene polymorphism, which has an important role in connective tissue and collagenous metabolism in stress urinary incontinence (SUI).
Materials and Methods: A total of 87 women with SUI who underwent normal vaginal delivery and 87 controls were involved in the study. Single nucleotide gene polymorphisms in LOX-L1's rs1048661, G > T, pArg141Leu, Exon-1 SmaI; rs3825942, C > T, pGly153Asp, Hinf-1 and rs2165241, C > T, İntron-1 BsrI regions were searched. The results were statistically compared as alleles with 3 × 2 χ2-test.
Results: A total of 32 (34%) GG, 20 (21%) GT, 42 (45%) TT, 32 (37%) GG, 43 (39%) GT, 21 (24%) TT polymorphisms in rs1048661; 30 (36%) CC, 16 (19%) CT, 37 (45%) TT, 41 (59%) CC, 15 (22%) CT, 13 (19%) TT polymorphisms in rs2165241; and 63 (72%) CC, 21 (24%) CT, 3 (4%) TT; 48 (6%) CC, 22 (30%) CT, 3 (4%) TT polymorphisms in rs3825942 were found in patients and the control group, respectively. In patients, the TT polymorphism in the rs1048661 and rs2165241 region were found to be significant.
Conclusions: The homozygote TT polymorphism in the rs1048661 and rs2165241 region of LOX-L1 gene may be responsible from SUI physiopathology.