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Sustained Neurotransmitter Release: New Molecular Clues
Article first published online: 7 APR 2006
DOI: 10.1111/j.1460-9568.1997.tb01679.x
1460-9568/asset/cover.gif?v=1&s=f24cc0b5582a6f8af7d83eee00b2056f825c5624 "European Journal of Neuroscience")
Additional Information
How to Cite
Brodin, L., Löw, P., Gad, H., Gustafsson, J., Pieribone, V. A. and Shupliakov, O. (1997), Sustained Neurotransmitter Release: New Molecular Clues. European Journal of Neuroscience, 9: 2503–2511. doi: 10.1111/j.1460-9568.1997.tb01679.x
Publication History
- Issue published online: 7 APR 2006
- Article first published online: 7 APR 2006
- Received 8 July 1997, accepted 5 August 1997
- Abstract
- References
- Cited By
Keywords:
- dynamin;
- endocytosis;
- exocytosis;
- synaptic vesicle;
- synapsin
Abstract
Chemical synapses convey impulses at high frequency by exocytosis of synaptic vesicles. To avoid failure of synaptic transmission, rapid replenishment of synaptic vesicles must occur. Recent molecular perturbation studies have confirmed that the recycling of synaptic vesicles involves clathrin-mediated endocytosis. The rate of exocytosis would thus be limited by the capacity of the synaptic clathrin machinery unless vesicles could be drawn from existing pools. The mobilization of vesicles from the pool clustered at the release sites appears to provide a mechanism by which the rate of exocytosis can intermittently exceed the rate of recycling. Perturbation of synapsins causes disruption of vesicle clusters and impairment of synaptic transmission at high but not at low frequencies. Both clathrin-mediated recycling and mobilization of vesicles from the reserve pool are thus important in the replenishment of synaptic vesicles. The efficacy of each mechanism appears to differ between synapses which operate with different patterns of activity.