Remodeling of reciprocal synapses associated with persistence of long-term memory

Authors

  • Masato Matsuoka,

    1. Division of Neurobiology and Anatomy, Department of Sensory and Integrative Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    2. Department of Physiology, School of Medicine, Virginia Commonwealth University, Sanger Hall, Room 3-012C, 1101 East Marshall Street, PO Box 980551, Richmond, VA 23298-0551, USA
    3. CREST of the Japan Science and Technology Corporation, Kawaguchi, Saitama, Japan
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  • Hideto Kaba,

    1. CREST of the Japan Science and Technology Corporation, Kawaguchi, Saitama, Japan
    2. Department of Physiology, Kochi Medical School, Nankoku, Kochi, Japan
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  • Keiko Moriya,

    1. CREST of the Japan Science and Technology Corporation, Kawaguchi, Saitama, Japan
    2. Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
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  • Junko Yoshida-Matsuoka,

    1. Division of Neurobiology and Anatomy, Department of Sensory and Integrative Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    2. Department of Physiology, School of Medicine, Virginia Commonwealth University, Sanger Hall, Room 3-012C, 1101 East Marshall Street, PO Box 980551, Richmond, VA 23298-0551, USA
    3. CREST of the Japan Science and Technology Corporation, Kawaguchi, Saitama, Japan
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  • Richard M. Costanzo,

    1. Department of Physiology, School of Medicine, Virginia Commonwealth University, Sanger Hall, Room 3-012C, 1101 East Marshall Street, PO Box 980551, Richmond, VA 23298-0551, USA
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  • Masao Norita,

    1. Division of Neurobiology and Anatomy, Department of Sensory and Integrative Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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  • Masumi Ichikawa

    1. CREST of the Japan Science and Technology Corporation, Kawaguchi, Saitama, Japan
    2. Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
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: Dr Masato Matsuoka, 1Division of Neurobiology and Anatomy, as above.
E-mail: winner@med.niigata-u.ac.jp

Abstract

We investigated a model of long-term memory in which the female mouse establishes pheromonal memory of its partner at mating. We examined the reciprocal synapses of the accessory olfactory bulb and found that pheromonal memory was associated with morphological changes in excitatory synapses in the early phase of memory acquisition and by changes in inhibitory synapses in the late phases of memory persistence. After extinction of pheromonal memory, these morphological changes were no longer present. These findings suggest that the persistence of pheromonal memory is associated with continuous and dynamic changes in the morphological plasticity of reciprocal synapses in the accessory olfactory bulb.

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