D.P.C. and P.G.F.B. contributed equally to this work.
Entorhinal cortex contributes to object-in-place scene memory
Version of Record online: 2 DEC 2004
European Journal of Neuroscience
Volume 20, Issue 11, pages 3157–3164, December 2004
How to Cite
Charles, D. P., Browning, P. G. F. and Gaffan, D. (2004), Entorhinal cortex contributes to object-in-place scene memory. European Journal of Neuroscience, 20: 3157–3164. doi: 10.1111/j.1460-9568.2004.03777.x
- Issue online: 2 DEC 2004
- Version of Record online: 2 DEC 2004
- Received 30 June 2004, revised 20 September 2004, accepted 30 September 2004
- entorhinal cortex;
- macaque monkey;
- object and spatial learning
Four rhesus monkeys (Macaca mulatta) were trained preoperatively in a test of object-in-place scene memory. They were presented daily with lists of unique computer-generated scenes each containing a spatial array of multiple individual objects. Within each scene, objects to be discriminated appeared in the foreground, each occupying a unique location, and monkeys were required to correctly discriminate the rewarded object to receive a food reward. Once this preoperative criterion was attained, the monkeys received bilateral entorhinal cortex ablation performed as either one or two surgical operations with a period of testing following each. Postoperatively, they were significantly impaired in learning new object-in-place scene problems. These results show that the entorhinal cortex, like anatomically related structures including the perirhinal cortex and the fornix, contributes to object-in-place scene learning.