M.S.R. and W.T. contributed equally to the work.
Galectin-1 in regenerating motoneurons
Article first published online: 2 DEC 2004
European Journal of Neuroscience
Volume 20, Issue 11, pages 2872–2880, December 2004
How to Cite
McGraw, J., McPhail, L. T., Oschipok, L. W., Horie, H., Poirier, F., Steeves, J. D., Ramer, M. S. and Tetzlaff, W. (2004), Galectin-1 in regenerating motoneurons. European Journal of Neuroscience, 20: 2872–2880. doi: 10.1111/j.1460-9568.2004.03802.x
- Issue published online: 2 DEC 2004
- Article first published online: 2 DEC 2004
- Received 21 May 2004, revised 3 October 2004, accepted 11 October 2004
- regeneration-associated genes;
The exogenous application of recombinant galectin-1 has recently been shown to promote the rate of peripheral nerve regeneration. Endogenous neuronal galectin-1 expression has recently been demonstrated to increase after axotomy. Here we demonstrate a significant increase in the endogenous neuronal expression of galectin-1 mRNA in facial motoneurons after either a nerve resection or crush injury in mice. This increase in galectin-1 expression was due in part to the loss of target-derived factor(s) as indicated by both the return of galectin-1 expression to control levels following target re-innervation and the increase in galectin-1 expression after blockade of axonal transport by an interneuronal colchicine injection. Furthermore, interneuronal injections of glial-derived neurotrophic factor into the uninjured nerve also increased galectin-1 mRNA expression within facial motoneurons suggesting that positive signals may also be involved in the regulation of galectin-1 expression. Galectin-1 null mutant mice showed an attenuated rate of functional recovery of whisking movement after a facial nerve crush.