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Regional cortical blood flow changes following sodium lactate infusion in Alzheimer's disease

Authors

  • János Kálmán,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • 1 András Palotás,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • 1,2 Gabriella Kis,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • 1 Krisztina Boda,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • 3 Piroska Túri,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • 1 Ferenc Bari,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • 4 Ferenc Domoki,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • 4 Ildikó Dóda,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • 1 Miklós Árgyelán,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • 1,6 Gábor Vincze,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • 5 Teréz Séra,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • 6 László Csernay,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • 7 Zoltán Janka,

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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  • and 1 László Pávics 6

    1. University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary
      1Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary; 2Division of Cardiac Surgery, Center for Cardiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary; 3Department of Medical Informatics, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary; 4Department of Physiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary; 5Department of Psychiatry, ‘Pándy Kálmán’ Municipality Hospital of Békés County, H-5700 Gyula, Semmelweis u. 1, Hungary; 6Department of Nuclear Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8, Hungary; 7International Medical Center, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary
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Dr András Palotás, University of Szeged, H-6720 Szeged, Pécsi u. 4, Hungary.
E-mail: palotas@nepsy.szote.u-szeged.hu

Abstract

Bilateral temporoparietal hypoperfusion is a characteristic single photon emission computed tomography (SPECT) finding in Alzheimer's disease (AD). Lactate is a metabolic vasodilator and is known to provoke increased cerebral blood flow (CBF) in healthy adults. This work investigated whether lactate, which is present in high concentrations in AD cerebrospinal fluid, affects AD-specific perfusion abnormalities. Twenty mild-to-moderately demented AD probands participated in the self-controlled study. The regional CBF was examined utilizing 99mTc-HMPAO SPECT after sodium lactate infusion (0.5 m, 5 mL/kg body weight) and 0.9% NaCl infusion, one on each of two separate days. Despite the vasodilatator effects of sodium lactate, AD rCBF patterns did not show increase in temporo-parietal regions after its infusion. AD-specific bi-temporo-parietal reduction in CBF was accompanied by further hypoperfusion in the parieto-occipital areas after the sodium lactate infusion in seven patients, while no CBF changes were observed in the case of the remaining 13 probands. The pattern of the CBF abnormalities was not correlated with the apolipoprotein E genotype. The decreased vascular responsiveness to sodium lactate reflects disturbed vasoregulatory processes in AD and it is unlikely that lactate would have any relevance in the treatment of AD-related cerebral hypoperfusion, but could be used to improve the value of perfusion SPECT in the diagnosis of AD.

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