Present address: Department of Otolaryngology, 2nd Floor, Eye and Ear Hospital, East Melbourne, Victoria, Australia 3002.
Clinical application of neurotrophic factors: the potential for primary auditory neuron protection
Article first published online: 1 NOV 2005
European Journal of Neuroscience
Volume 22, Issue 9, pages 2123–2133, November 2005
How to Cite
Gillespie, L. N. and Shepherd, R. K. (2005), Clinical application of neurotrophic factors: the potential for primary auditory neuron protection. European Journal of Neuroscience, 22: 2123–2133. doi: 10.1111/j.1460-9568.2005.04430.x
- Issue published online: 1 NOV 2005
- Article first published online: 1 NOV 2005
- Received 11 May 2005, revised 8 August 2005, accepted 5 September 2005
- neural protection;
- cochlear implant
Sensorineural hearing loss, as a result of damage to or destruction of the sensory epithelia within the cochlea, is a common cause of deafness. The subsequent degeneration of the neural elements within the inner ear may impinge upon the efficacy of the cochlear implant. Experimental studies have demonstrated that neurotrophic factors can prevent this degeneration in animal models of deafness, and can even provide functional benefits. Neurotrophic factor therapy may therefore provide similar protective effects in humans, resulting in improved speech perception outcomes among cochlear implant patients. There are, however, numerous issues pertaining to delivery techniques and treatment regimes that need to be addressed prior to any clinical application. This review considers these issues in view of the potential therapeutic application of neurotrophic factors within the auditory system.