Nicotinic modulation of glutamatergic synaptic transmission in region CA3 of the hippocampus

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In the paper of Giocomo et al. (2005), three of the figures were placed incorrectly: the graphic above legend 6 was actually Fig. 8, the graphic above legend 7 was actually Fig. 6, and the graphic above legend 8 was actually Fig. 7. We apologise for any inconvenience caused, and reproduce the three figures and their legends again here.

Figure 8.

Combined plot of five experiments involving the bath application of 100 µm nicotine in the presence of 10 nm MLA. Error bars are plotted every 10 points. Application of MLA resulted in a significant decrease in the suppression of synaptic transmission and no significant change in the later enhancement effect of nicotine on evoked synaptic potentials.

Figure 6.

Combined plot of five experiments involving the bath application of 100 µm nicotine in the presence of 100 µm picrotoxin. Error bars are plotted every 10 points. Only the application of nicotine is indicated in the figure as the picrotoxin was applied continuously throughout the experiment. Application of nicotine in the presence of picrotoxin resulted in no change in synaptic transmission, indicating that picrotoxin completely blocked the effect of the 100 µm nicotine. After the application of the nicotine, the picrotoxin caused some instability in the potentials observed, as indicated by the larger error bars after nicotine was discontinued.

Figure 7.

Combined plot of five experiments involving the bath application of 100 µm nicotine in the presence of 10 µm MEC. Error bars are plotted every 10 points. Application of MEC resulted in the complete absence of any suppression of synaptic transmission, and a significant decrease in the later enhancement effect of nicotine on evoked synaptic potentials.

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