Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness

Authors

  • R. Cediel,

    1. Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Arturo Duperier 4, Madrid 28029, Spain
    2. Department Medicina y Cirugía, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid 28040, Spain
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  • R. Riquelme,

    1. Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Arturo Duperier 4, Madrid 28029, Spain
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  • J. Contreras,

    1. Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Arturo Duperier 4, Madrid 28029, Spain
    2. Department Anatomía, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid 28040, Spain
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  • A. Díaz,

    1. Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Arturo Duperier 4, Madrid 28029, Spain
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  • I. Varela-Nieto

    1. Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Arturo Duperier 4, Madrid 28029, Spain
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Dr Isabel Varela-Nieto, as above.
E-mail: ivarela@iib.uam.es

Abstract

It has been reported that mutations in the gene encoding human insulin-like growth factor-I (IGF-I) cause syndromic hearing loss. To study the precise role of IGF-I in auditory function and to hypothesize the possible morphological and electrophysiological changes that may occur in the human inner ear, we have analysed the auditory brainstem response in a mouse model of IGF-I deficiency. We show here that homozygous Igf-1/ mice present an all-frequency involved bilateral sensorineural hearing loss. Igf-1–/– mice also present a delayed response to acoustic stimuli; this increases along the auditory pathway, indicating a contribution of the central nervous system to the hearing loss in Igf-1–/– mice. These results support the use of the Igf-1–/– mouse as a new model for the study of human syndromic deafness.

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