Cell and molecular mechanisms involved in the migration of cortical interneurons

Authors

  • Christine Métin,

    1. Developpement Normal et Pathologique du Cerveau, INSERM, U616, 47 Boulevard de l'Hôpital, F-75651 Paris Cédex 13, France
    2. IFR 70, Université Pierre et Marie Curie, Hôpital de la Salpêtrière, F-75651 Paris Cédex 13, France
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  • Jean-Pierre Baudoin,

    1. Developpement Normal et Pathologique du Cerveau, INSERM, U616, 47 Boulevard de l'Hôpital, F-75651 Paris Cédex 13, France
    2. IFR 70, Université Pierre et Marie Curie, Hôpital de la Salpêtrière, F-75651 Paris Cédex 13, France
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  • Sonja Rakić,

    1. Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
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  • John G. Parnavelas

    1. Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
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Dr John Parnavelas, as above.
E-mail: j.parnavelas@ucl.ac.uk

Abstract

Since the discovery that the vast majority of the GABA-containing interneurons of the cerebral cortex arise in the subpallium, considerable effort has been put into the description of the precise origin of these neurons in subdivisions of the ganglionic eminence and in the migratory routes they follow on their way to the developing cortex. More recently, studies have focused on the molecular and cellular mechanisms that guide their migration. Investigations of the molecular mechanisms involved have demonstrated important roles for numerous transcription factors, motogenic factors and guidance molecules. Here, we review results of very recent analyses of the underlying cellular mechanisms and specifically of the movement of the nucleus, cytoplasmic components and neuritic processes during interneuron migration.

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