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Temporal and spatial alterations in GPi neuronal encoding might contribute to slow down movement in Parkinsonian monkeys

Authors

  • Arthur Leblois,

    1. Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université Victor Segalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
    2. Laboratoire de Neurophysique et Physiologie, CNRS UMR 8119, Université René Descartes, 45 rue des Saints Pères, 75270, Paris Cedex, France
    3. Laboratoire franco-israelien de neurophysiologie et neurophysique des systèmes, Université Victor Ségalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
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  • Wassilios Meissner,

    1. Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université Victor Segalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
    2. Département de Neurologie, CHU Pellegrin, 1 place Amélie Raba-Léon, 33076 Bordeaux, France
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  • Erwan Bezard,

    1. Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université Victor Segalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
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  • Bernard Bioulac,

    1. Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université Victor Segalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
    2. Laboratoire franco-israelien de neurophysiologie et neurophysique des systèmes, Université Victor Ségalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
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  • Christian E. Gross,

    1. Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université Victor Segalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
    2. Laboratoire franco-israelien de neurophysiologie et neurophysique des systèmes, Université Victor Ségalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
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  • Thomas Boraud

    1. Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université Victor Segalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
    2. Laboratoire franco-israelien de neurophysiologie et neurophysique des systèmes, Université Victor Ségalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
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Dr A. Leblois, 2CNRS UMR 8119, as above.
E-mail: leblois@clipper.ens.fr.

Abstract

Although widely investigated, the exact relationship between changes in basal ganglia neuronal activity and parkinsonian symptoms has not yet been deciphered. It has been proposed that bradykinesia (motor slowness) is related either to a modification of the activity of the globus pallidus internalis (GPi), the main output structure, or to a loss of spatial selectivity of the extrapyramidal motor system. Here we investigate the relationship between movement initiation and GPi activity in parkinsonian non-human primates. We compare neuronal encoding of movement in the normal and pathological conditions. After dopamine depletion, we observe an increased number of neurons responding to movement, with a less specific somato-sensory receptive field and a disruption of the selection mechanism. Moreover, the temporal order of the response of GPi neurons in parkinsonian animals is reversed. Indeed, whereas muscle activity and movement are delayed in parkinsonian animals, GPi neuronal responses to movement occur earlier and are prolonged, compared with normal conditions. Parkinsonian bradykinesia could thus result from an impairment of both temporal and spatial specificity of the GPi response to movement.

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